Diyvehiclerepair
- Why is Xist necessary?
- What does Xist stand for?
- What is the product of Xist?
- Does Xist regulate transcription?
- What does the Xist gene do and why is only expressed in females?
- What is Xist chromosome therapy?
- Do men have the Xist gene?
- Can xist affect DNA methylation?
- Is Xist RNA cis acting?
- What type of RNA is Xist quizlet?
- How long is the Xist gene?
- Where is the Xist RNA translated?
- What is Euchromatic nucleus?
- What is the purpose of Pseudoautosomal regions?
Why is Xist necessary?
It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. ... The Xist gene, therefore, not only has a role in chromatin remodeling, but also includes an element required for X chromosome choosing.
What does Xist stand for?
Xist (X-inactive specific transcript) is a non-coding RNA on the X chromosome of the placental mammals that acts as a major effector of the X-inactivation process. It is a component of the Xic – X-chromosome inactivation centre – along with two other RNA genes (Jpx and Ftx) and two protein genes (Tsx and Cnbp2).
What is the product of Xist?
The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell. 1992 Oct 30;71(3):515-26. doi: 10.1016/0092-8674(92)90519-i.
Does Xist regulate transcription?
2001; Rougeulle et al. 2004). These epigenetic marks may contribute to transcriptional regulation of one or more genes in the region, including Xist itself, and may result from ongoing bidirectional transcription in this region as well as from immediate recruitment of PRC2 by nascent Xist transcripts.
What does the Xist gene do and why is only expressed in females?
Background. X inactive-specific transcript (XIST) RNA is involved in X chromosome silencing in female cells and allows X chromosome equilibration with males.
What is Xist chromosome therapy?
XIST is a long non-coding RNA that functions in cis to silence one X chromosome to dosage compensate X-linked genes between females (XX) and males (XY).
Do men have the Xist gene?
XIST RNA is only expressed in cells containing at least two Xs and is not normally expressed in male cells (Figure 2). Higher XIST expression can be seen in cells with more X chromosomes, as a counting mechanism dictates that only one X per cell can remain active.
Can xist affect DNA methylation?
In addition, Xist and Tsix negatively regulate each other, raising the possibility that Tsix also has a role in regulation of Xist DNA methylation. Tsix has also been implicated in the direct regulation of DNA methylation.
Is Xist RNA cis acting?
Xist lies within the X-inactivation center (Xic), a region on the X that is required for XCI, and is regulated in cis by elements on the X chromosome and in trans by diffusible factors.
What type of RNA is Xist quizlet?
The Xist gene is considered to be a non-coding RNA (ncRNA), Xist gene is for protection of the genome. X chromosome inactivation form what are called Barr bodies. The Xist gene contain an antisense gene to stop the function of inactivating the X chromosome.
How long is the Xist gene?
Xist encodes a 17-kb long non-coding RNA (lncRNA) that, despite being capped, spliced and poly-adenylated, is retained in the nucleus. In mouse, XCI occurs in two different fashions.
Where is the Xist RNA translated?
Xist RNA, required for X chromosome inactivation, is transcribed from the future inactivated X chromosome (Xi), where it spreads in cis, to initiate silencing.
What is Euchromatic nucleus?
Euchromatin is a lightly packed form of chromatin (DNA, RNA, and protein) that is enriched in genes, and is often (but not always) under active transcription. ... 92% of the human genome is euchromatic. In eukaryotes, euchromatin comprises the most active portion of the genome within the cell nucleus.
What is the purpose of Pseudoautosomal regions?
The function of these pseudoautosomal regions is that they allow the X and Y chromosomes to pair and properly segregate during meiosis in males.
